Clinical Randomisation of an Anti-fibrinolytic in Symptomatic mild Head injury in older adults
Intramuscular tranexamic acid for the treatment of symptomatic mild traumatic brain injury in older adults: a randomised, double-blind, placebo-controlled trial
Guide to enrollment
First decide if the patient is eligible:
Inclusion Criteria:
- Aged 50yrs or over
- History or evidence of HI (for example: laceration; bruising; swelling or pain in head or face)
- GCS – 13, 14 or 15
- Has had one or more of:
- LOC &/or Amnesia &/or Confusion &/o Drowsy
- Nausea and/or Vomiting
- Within 3hrs of injury
Exclusion Criteria:
- Lives in nursing home, mental health institution or prison
- Over 3hrs since injury or time unknown
- TXA is clearly indicated due to other injuries, or contraindicated
If the patient is eligible:
Step by Step Guide to Recruitment:
In normal working hours:
- Send the ED Research Team a message via Epic chat "ED research Team" or phone 217907
Out of hours and weekends:
- Collect paperwork from magazine rack in ambulance bay near the automatic doors
- Consent Patient (or obtain from family member or an uninvolved Dr who can act as Professional Representative if patient lacks capacity) and provide Patient Information Sheet
- Obtain syringe pack from the Research cupboard in Area B – take the next pack in numerical order (key to unlock cupboard is with the resus room nurse in charge)
- Find a Dr able to prescribe (see link)
- Place order using “CRASH4” and type in trial pack number from the above pack (xxxx/xxx)
- Administer IM injection to patient (either 1x5ml or 2x 2.5ml), give them the wristband, sign on MAR (including counter-sign)
- Document in EPIC using smartphrase .CRASH4
- Complete paper ENTRY FORM in paperwork pack
- Place ALL paperwork in the research letterbox (on the wall behind the receptionists)
- Send ED Research Team an EPIC chat message with patient details - it'll be picked up the following shift
